Academic Experts
Academic Experts
Prof. Indira P. Sarethy
Professor
indirap.sarethy@jiit.ac.in
Biography

My research lies at the intersection of bioresources and natural products, with a focus on harnessing the therapeutic and industrial potential of microbial and plant biodiversity. In our culture-dependent investigations, we isolate and characterize microorganisms from niche habitats—including deserts, forests, lichens, limestone rocks, heritage monuments, inland water bodies and endophytic associations—aiming to identify bioactive compounds with significant applications. Complementing this, the metagenomics research seeks to understand the uncultivable novel biodiversity, thus expanding the scope of discovery beyond cultivable species. Whole Genome Sequencing studies on selected microorganisms have revealed interesting insights on the unharnessed potential in bioactivity. Metaviromic studies focus on understanding the virus portfolio in the environment and possibilities of utilizing them in targeting antibiotic resistance. Our group has developed strong capabilities in leveraging taxonomic identity and dovetailing novel species with hitherto undiscovered natural bioactive metabolites. 

The work extends to fermented food products, where bioactivity is scientifically evaluated and the contributing microbial diversity is mapped to understand and validate their functional properties. This work proposes utilizing traditional knowledge base to develop functional food tailored to address modern lifestyles. Further, utilizing microorganisms to develop soil conditioners to address peri-urban soil degradation is in progress.

My group’s work contributes to advancing sustainable resource utilization while deepening our understanding of microbial and plant biodiversity as reservoirs of innovation for health, industry, and the environment. bridges fundamental biodiversity studies with real-world applications in waste management, industrial biotechnology, and health-related innovations.

As Associate Dean (Programme Coordinator for online courses (NPTEL), Ranking, Interfacing for Perception & Collaboration Enhancement), my mandate is to contribute to dissemination of information on MOOC courses, coordination with students and SWAYAM and disseminate guidelines.

Research Highlights
  • Understudied habitats have been used for exploration of microbial diversity and natural product discovery using cultivable and metagenomic approaches.
  • Novel anti-cancer, antimicrobial and antioxidant compounds have been characterized
  • New actinobacterial taxa from the Thar Desert have been taxonomically characterized
  • Microbial profiling of Sulphur-rich water from an ancient stepwell has revealed unique extremophilic microbial communities.
  • Microbial metabolites (biosurfactants, enzymes, siderophores) have been characterized for bioremediation, soil conditioning, and industrial applications.
  • Fermentation process optimization and microbial profiling of traditional foods to enhance nutritional, therapeutic, and preservation attributes.
  • hypertensive properties of milk derived- bioactive peptides fermented by lactic acid bacteria.
Areas Of Interest
  • Microbial biotechnology
  • Environmental Biotechnology
  • Bioresources
  • Functional Foods
Patents
  • Patent title: “NOVEL ANTIMICROBIAL METABOLITES OBTAINED BY A NEW PROCESSING METHOD FROM RARE ACTINOBACTERIUM (Nonomuraea sp. RK-328)” 
    Granting id: Patent Application No.: 202211064813 dated 12.11.2022, published 25/11/2022 
    Specification:The present invention relates to the process of extraction and characterization procedure of antimicrobial compounds and more particularly, extraction and characterization procedure of antimicrobial compounds from potentially novel and rare actinobacteria Nonomuraea species