Academic Experts
Academic Experts
Dr. Shalini Mani
Associate Professor
shalini.mani@jiit.ac.in
Biography

Dr. Shalini Mani is Associate Professor in the Department of Biotechnology at Jaypee Institute of Information Technology, Noida, India. She has total 22 years of research and 15 years of teaching experience. She completed her PhD from Centre for Cellular and Molecular Biology, Hyderabad, where she worked on detailed analysis of clinical biochemical and genetic analysis of Leigh syndrome patients and found an interesting genotype-phenotype correlation of mitochondrial and nuclear gene mutations in these patients. She also found an interesting thiamine deficiency in these patients, which was otherwise declared to be irradiated from India.
She did her post-doctorate from Murdoch Children Research Institute, Melbourne Australia. During her post doctorate, she has been awarded with one of the prestigious awards of Endeavor Research fellowship, Australia. During her post-doc, Dr Mani studied the therapeutic efficiency of nicotinamide-riboside in cardiomyopathy using Ndufs4 and Ndufs6 Complex I deficient mice model. 
Dr. Mani has actively engaged in several national and international conferences, showcasing her research across India and overseas. Her academic portfolio is notable, encompassing 60 publications in international journals, 32 book chapters, and three authored books. She also exhibits a strong dedication to innovation, evidenced by a filed and published patent. 
Dr Mani is also a recipient of outstanding award for “Women in Oncology Research” in 2021 by Indian Pharmacopeia Commission, India. 
 

Research Highlights

Mitochondria, being a powerhouse of the cellular system are a most important organelle. Along with ATP generation it also helps in removal of oxidative stress from the system. Hence, any perturbation in mitochondrial metabolism may affect several organs and hence cause several diseases/disorders. In the last decade only, research based on various aspects of mitochondria started coming in to the picture. As result of which mitochondrial defects are suggested to be associated with a large number of metabolic and neurological disorders. However, the research exploring the detailed mechanism of participation of mitochondria, it’s possible defects etc in causation and or progress of the large number of diseases are still in infancy. Hence, currently my primary research interest is to explore the mechanism of pathogenic role of mitochondria in common metabolic diseases like cancer and diabetes. To understand the same, my lab is mainly focusing on, bioenergetics of cell system, redox imbalance, mitochondrial genome instability, copy number variation of mtDNA, its possible genetics and mitochondrial- nuclear cross talk during cancer and diabetes.

Areas Of Interest
  • Mitophagy in Chemoresistance
  • Drug repurposing
  • Mitochondria Tragetting in Neurological disorders
  • Mitocans
  • Vitamin D deficiency
Publications
  • Mani S, Wasnik S, Shandilya C, Srivastava V, Khan S and Singh KK (2025) Pathogenic synergy: dysfunction mitochondria and neuroinflammation in neurodegenerative diseases associated with aging. Front. Aging 6:1615764. doi: 10.3389/fragi.2025.1615764 (Indexed in Scopus, IF- 4.3).
     
  • Mani S, Srivastava V, Shandilya C, Kaushik A, Singh KK. Mitochondria: the epigenetic regulators of ovarian aging and longevity. Front Endocrinol (Lausanne). 2024 Nov 13; 15:1424826. doi: 10.3389/fendo.2024.1424826. PMID: 39605943; PMCID: PMC11598335. (Indexed in Scopus, PubMed, IF- 4.0).
     
  • Aditi K, Saboor K, Nandini P and Shalini M., Dual pH and ultrasound responsive nanocarriers: A smart approach in cancer theranostics, Journal of Drug Delivery Science and Technology, Volume 95, 2024, 105560, https://doi.org/10.1016/j.jddst.2024.105560. (Indexed in Scopus, PubMed, IF- 4.5).
     
  • Mani, S, Ralph, S., Swargiary, G., Rani, M., Wasnik, S., Singh, S.P. and Devi, A., 2023. Therapeutic Targeting of Mitochondrial Plasticity and Redox Control to Overcome Cancer Chemoresistance. Antioxidants and Redox Signaling, (ja). July 2023. (Indexed in Scopus, PubMed, IF- 5.9).
     
  • Mani, S., Jindal, D., Chopra, H., Jha, S.K., Singh, S.K., Ashraf, G.M., Kamal, M., Iqbal, D., Chellappan, D.K., Dey, A. and Dewanjee, S., 2022. ROCK2 Inhibition: A Futuristic Approach for the Management of Alzheimer’s Disease. Neuroscience & Biobehavioral Reviews, p.104871. (IF-9.02).